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How to Treat Complications of PKD (Polycystic Kidney Disease)

 

How to Treat Complications of PKD (Polycystic Kidney Disease)

How to Treat Complications of PKD (Polycystic Kidney Disease)

PKD (Polycystic Kidney Disease) is presented by heredity, meaning the disease is passed down from family members. The disease can be treated by general or conventional treatments, like renal cyst decortications. What about its complications? How to treat complications of Polycystic Kidney Disease? Read on to find the answer.

General treatments

Most of the PKD patients have no need to make significant lifestyle changes. Only for those with big renal cysts, abdominal trauma should be prevented so as to stop the rupture of cysts.

Apart from diet and lifestyle modification, dialysis and kidney transplant are frequently needed to deal with end stage PKD.

Renal cyst decortications

Renal cyst decortication is one typical treatment of western medicines. It, indeed, releases the pressure coming from kidney cysts to renal parenchyma, and also protects the remaining kidney function from being damaged. It can help improve renal ischemia and anoxia also. Operating as early as possible could improve the therapeutic effect as much as possible. This kind of treatment is clearly limited, because it can’t remove numerous cysts one by one, which lays the foundation for further relapse. Besides, if the Polycystic Kidney Disease patients have already suffered from renal failure, there’s no point to perform this surgery.

Hematuria

Finding out the causes of hematuria is the first thing we should do, and treatments are required. For PKD patients with blood in urine, they had better stay in bed.

Infections

Renal parenchyma infection or infections in cysts become the major complications of Polycystic Kidney Disease. Antibiotics will be adopted to deal with infections.

Those who often have urinary tract infection and kidney stones

Finding out the location of kidney stones and its size, and treat this complication just like kidney stones.

High blood pressure

The activation of RAAS (rennin-angiotensin- aldosterone system) and renal ischemia is the primary cause of high blood pressure. Hypotensors are necessary.

Chinese medicine

Certain Chinese herb medicine is beneficial for slowing down the progression of this disease. Herbs like pseudo-ginseng and turtle shell are often used for kidney cysts.

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PKD and Kidney Failure

Metabolic acidosisKidney failure occurs when you are left with less than 10-15% of total kidney function. When the kidneys fail, dialysis treatment or a kidney transplant is needed. Not everyone with PKD will go on to develop kidney failure. On average, half of the people with the Type 1 variant of ADPKD will require treatment for kidney failure by age 60. However, people affected with the Type 2 variant have a lower risk for developing kidney failure. Children born with ARPKD usually develop kidney failure within a few years.

There are treatments available that help to delay progression of ADPKD.

Pharmacologic therapy is necessary to accomplish the following:

Control blood pressure

Control abnormalities related to renal failure

Treat urinary tract infections

Treat hematuria

Reduce abdominal pain produced by enlarged kidneys

Metabolic problems related to renal failure that need to be controlled include the following:

Hyperkalemia

Hyperphosphatemia

Hypocalcemia

Hyperparathyroidism

Metabolic acidosis

Recent research has led to the development of Chinese herbal medicine that may shrink cysts and prevent cysts from developing.

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Polycystic Kidney Disease with Blood in Urine

Blood in Urine

Blood in Urine

Polycystic kidney disease is a hereditary renal disease in which the kidneys are filled with numerous cysts of varying sizes. With the progressing of the disease condition, patients will often have blood in urine. Is blood in urine a serious condition and will it aggravate PKD?

Blood in urine is a common symptom of PKD and there are more than a half of PKD cases have this experience. When the bleeding is severe, it can cause renal colic when blood clots pass ureters. Blood in urine is often accompanied by leucocyte urine and protein in urine(usually less than 1.0g/d). If there is infection or inflammation in the kidneys, blood in urine will be worsened and there will also be obvious pyuria, back pain and fever.

What are the possible causes of blood in urine?

Blood in urine is mainly caused by the following reasons. One is renal hematuria. The compression of continuously enlarged cysts to surrounding renal tissues will damage the renal functional units and start the process of renal fibrosis. The glomerular basement membrane is damaged and its permeability is increased, as a result, the blood cells will pass through the glomerular filtration membrane and be discharged into urine and form hematuria. The other reason is rupture of blood vessels due to enlarged cysts. In addition, blood in urine can be caused by other reasons such as urinary tract infection, kidney stone or cancerization. If blood in urine lasts for more than one week or the patient is older than 50 years old, related tests should be done to rule out the possibility of cancerization.

What are the damage and danger of blood in urine?

Once there is blood in urine, patients are easy to have abdominal infection, high fever, systemic edema and sharp decline of renal function. Since blood urine in PKD is highly recurrent, patients are easy to have anemia—there will be sharp decrease of platelet and the blood coagulation mechanism will also be affected. In serious condition, it might cause renal failure.

What are the treatments for blood urine in PKD?

Since there are several causes of blood urine, the first step is to make clear the exact cause and remove it. Besides, patients should stop working and have good rest.

After blood in urine, most PKD patients develop infections which will in turn worsen hematuria, therefore proper prevention and treatments for infections are necessary.

Then more effective treatments should be offered to eliminating blood stasis and improving blood circulation. Whether it is the damaged glomerular filtration membrane or ruptured blood vessels, the root problem is the continuous enlargement of the cysts. Herbal medicines have good effect on alleviating hematuria in PKD. Active material from natural plants will provide necessary nutrition for repairing damaged renal tissues and improving renal function.

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Polycystic Liver Disease (PLD)-A Complication of PKD

Autosomal Dominant Polycystic Kidney Disease (ADPKD) can cause cysts to develop in other parts of your body. Polycystic Liver Disease (PLD) is one of the most common complications of PKD, particularly in elder people. About 40-70% of people with ADPKD develop cysts in the liver which is known as Polycystic Liver Disease (PLD).

Liver cysts can affect men and women, but women seem to have more cysts that grow to larger sizes and develop at an earlier age, which is thought to be associated with female hormones like oestrogen. The cysts does not usually influence the normal liver function, but sometimes can cause some symptoms such as swelling and bloating of your abdomen, abdominal pain and yellowing of the eyes and skin.

In most cases the symptoms of Polycystic Liver Disease (PLD) will disappear without the need for treatment; in rare cases, when a larger cyst causes severe and persistent pain, surgery may be used to drain the cyst; In very rare cases, the liver becomes so massively swollen that it stops working properly. It may be necessary to remove part of the liver by surgery or perform a complete liver transplant.

There is not much you can do to prevent the growth of liver cysts if you have PLD. Researchers are currently studying whether the drug octreotide (Sandostatin), given intravenously or by injection, can decrease the number of liver cysts associated with PLD. So far, the results have been mixed.

If you have been recently diagnosed with polycystic liver disease , don’t worry. Most people with the condition have few if any symptoms and live normal, productive lives. If you do have pain and are suffering from PLD, tell your doctor. The doctor will be able to guide you towards the most appropriate treatment.

In China, Chinese herbal medicine may be another choice for patients with PLD. Just likes Polycystic Kidney Disease (PKD), the key of treatment is to skink the cysts growing on kidney or liver. The Chinese herbal medicine can expand the blood vessels, promote blood circulation and remove blood stasis. If the patients continue with the treatment for a whole course, the cysts will be softened or even shrunk. It is preventative treatment and can protect the kidney and liver function. If the cysts are numerous, this conservative treatment is better than surgery, because it acts on all the cysts at the same time, not only one big cyst and is safer.

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How is autosomal dominant PKD diagnosed

pkd

pkd

Autosomal dominant PKD is usually diagnosed by kidney imaging studies. The most common form of diagnostic kidney imaging is ultrasound, but more precise studies, such as computerized tomography (CT) scans or magnetic resonance imaging (MRI) are also widely used. In autosomal dominant PKD, the onset of kidney damage and how quickly the disease progresses can vary. Kidney imaging findings can also vary considerably, depending on a patient’s age. Younger patients usually have both fewer and smaller cysts. Doctors have therefore developed specific criteria for diagnosing the disease with kidney imaging findings, depending on patient age. For example, the presence of at least two cysts in each kidney by age 30 in a patient with a family history of the disease can confirm the diagnosis of autosomal dominant PKD. If there is any question about the diagnosis, a family history of autosomal dominant PKD and cysts found in other organs make the diagnosis more likely.

In most cases of autosomal dominant PKD, patients have no symptoms and their physical condition appears normal for many years, so the disease can go unnoticed. Physical checkups and blood and urine tests may not lead to early diagnosis. Because of the slow, undetected progression of cyst growth, some people live for many years without knowing they have autosomal dominant PKD.

Once cysts have grown to about one-half inch, however, diagnosis is possible with imaging technology. Ultrasound, which passes sound waves through the body to create a picture of the kidneys, is used most often. Ultrasound imaging does not use any injected dyes or radiation and is safe for all patients, including pregnant women. It can also detect cysts in the kidneys of a fetus, but large cyst growth this early in life is uncommon in autosomal dominant PKD.

More powerful and expensive imaging procedures such as CT scans and MRI also can detect cysts. Recently, MRI has been used to measure kidney and cyst volume and monitor kidney and cyst growth, which may serve as a way to track progression of the disease.

An ultrasound imaging device passes harmless sound waves through the body to detect possible kidney cysts.

Diagnosis can also be made with a genetic test that detects mutations in the autosomal dominant PKD genes, called PKD1 and PKD2. Although this test can detect the presence of the autosomal dominant PKD mutations before large cysts develop, its usefulness is limited by two factors: detection of a disease gene cannot predict the onset of symptoms or ultimate severity of the disease, and if a disease gene is detected, no specific prevention or cure for the disease exists. However, a young person who knows of a PKD gene mutation may be able to forestall the loss of kidney function through diet and blood pressure control. The genetic test may also be used to determine whether a young member of a PKD family can safely donate a kidney to a family member with the disease. Individuals with a family history of PKD who are of childbearing age might also want to know whether they have the potential of passing a PKD gene to a child. Anyone considering genetic testing should receive counseling to understand all the implications of the test.

you can see this link to know How To Treat Polycystic Kidney Disease

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How to Control High Blood Pressure for PKD Patients

High Blood Pressure

High Blood Pressure

High blood pressure is one of the early symptoms of PKD. There are about 50% young PKD patients have blood pressure higher than 140-90mmHg and nearly all patients develop high blood pressure in end stage PKD.

To learn how to control and treat high blood pressure, first let’s see what is the normal value of blood pressure and what is called hypertension.

Normal blood pressure

Systolic blood pressure<130mmHg

Diastolic blood pressure<85mmHg

Ideal blood pressure

Systolic blood pressure<120mmHg

Diastolic blood pressure<80mmHg

The normal upper limit of blood pressure

Systolic blood pressure 130-139mmHg

Diastolic blood pressure 85-89mmHg

The following are some suggestions for controlling blood pressure in daily life for PKD patients.

Some beneficial foods: hawthorn, black fungus, celery, chrysanthemum tea.

Some beneficial exercises: walking, jogging, Tai Chi, etc.

While doing exercises, patients should avoid strenuous activities or abdominal traumas so as to lower the risk of rupture of these multiple continuously enlarged cysts in patients’ kidneys.

Besides these conventional measures for controlling blood pressure, PKD patients should not forget the root problem—these numerous renal cysts. Continuously enlarged and increased cysts will oppress normal renal tissues and cause ischemia, hypoxia and low blood perfusion in the kidneys, thus causing high blood pressure. If not treated well, high blood pressure will in turn worsen renal damage. Only if the cysts are shrunk or removed and further enlargement of these cysts are controlled, can the renal oppression be relieved and renal fibrosis be reversed.

Surgery is a good method to remove renal cyst in short time, however it is more suitable to treat simple and single cyst and not very proper for PKD. What is more, the formation of cysts in PKD is gene-related and there are numerous cysts which vary in size, so it is impossible to be treated through surgery.

From this regard, Chinese herbal medicines has better curative effects than surgery in the long run. This is because herbal medicines can have overall effects on shrinking both small and large cysts.

Controlling blood pressure has a lot of benefits for PKD patients. High blood pressure is a major risk factor for speeding up deterioration of kidney function and therefore a relatively low and stable blood pressure can enable a better prognosis for PKD patients.

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How To Treat and Prevent of PKD Disease

pkd-symptomsAs PKD disease will develop as age, you can do some early prevention and treatment to improve the systemic condition and slow down the progress of the disease. From the pathology of PKD disease, the patient will occur high blood pressure in one’s 30s; as the cysts grow in size and number, the kidney functions will be influenced with elevated serum creatinine level and some other symptoms in one’s 40s; there will occur kidney failure in one’s 50th, then the patient will have to do dialysis or kidney transplant.

At present, Micro-Chinese Medicine Osmotherapy has a good effect on shrinking the size of the cysts, controlling the disease and relieving the symptoms. If the kidney function has been damaged a lot, stem cell therapy is also needed to differentiate into new functional cells of the kidneys to replace the dead ones, so as to improve the kidney function and change the gene environment for the cysts. Therefore, the disease can be well controlled and its progress can be slowed down.

The cysts in your both kidneys were 4.2×3.8cm and 5.3×4.0cm respectively, they are alittle bigger. In fact, when the cysts are bigger than 3cm, they will begin to dodamage to your kidneys.

PKD disease will develop as age, the patient will occur high bloodpressure in one’s 30s; as the cysts grow in size and number, the kidneyfunctions will be influenced with elevated serum creatinine level and some othersymptoms in one’s 40s; there will occur kidney failure in one’s 50th, then thepatient will have to do dialysis or kidney transplant.

Since your grandmother and great-grandmotherdied from the disease and your father also has it as well, you must know howawful this disease is.

Fortunately, there is a way to control oreven to shrink the cysts in our hospital, Micro-Chinese Medicine. It is thecontinuing secretion of cystic fluid that causes the growth of cysts and Micro-Chinese Medicine can change the cells not to let them to produce suchfluid. What’s more, Micro-Chinese Medicine can promote blood circulation,including the blood circulation around cysts, as a result, some fluid can betaken away and the cysts will be shrunk naturally.

You must know the earlier treatment is, thebetter result will get. You are so young and your physical conditions are inthe best period, if treat in time,you will have an satisfactory result.

Learn about What Symptoms of PKD Disease 

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