Tag Archives: PKD Basic

Traditional Chinese Medicines(TCM) For PKD

Traditional Chinese Medicines(TCM) For PKD

Traditional Chinese Medicines(TCM) For PKD

About the treatment for PKD, we have many therapies, such as TCM, micro-Chinese medicine osmotherapy and Immunotherapy. I will emplain them for you in detail.

1. Traditional Chinese Medicines ( TCM )

As we know the continuous deterioration of renal function is caused by the progressive enlargement and increase of the cysts, therefore the key point is to slow down their growth rate and try to shrink them to smaller size. In this regard, Tradition Chinese Medicines have particularly good effects on shrinking these multiple cysts and at the same time regulating disorders and repairing kidney damages. Though it take relatively longer time to take effect compared with western therapies, its curative effects can last for a long time since it deal with the disease from the root. And what is more it has far fewer side effects and injuries to the body. Even though, many patients are reluctant to take TCM due to its bitterness, inconvenience and slow effects.

2. Micro-Chinese Medicine Osmotherapy

Micro-Chinese Medicine Osmotherapy is a creation and innovation based on TCM. It can slow down the growth rate of the cysts and shrink the cysts.

Its mechanism in shrinking cysts;

1. Expand blood vessels around the cysts, speed up blood circulation and increase the permeability of the cyst wall. This will lower the intravascular pressure and cause cystic fluids to be re-absorbed to the blood vessels and be taken away with blood circulation.

2. The active ingredients in Micro-Chinese Medicines can deactivate the epithelial cells and inhibit the continuous secretion of cystic fluid so as to prevent further swelling of the cysts and blood vessels in the cyst wall. At the same time these medicines can provide necessary nutrition for repairing renal damaged cells and tissues.

Its curative effects:

① Reduce the secretion of cystic fluids and alleviate oppression to glomeruli, renal tubules and blood vessels, speed up blood circulation and improve hypoxia and ischemia.

② Active ingredients in the medicines can block the deterioration chain of renal fibrosis and protect the remaining functional renal intrinsic cells from further damages.

③ Micro-Chinese Medicines can provide materials for repairing damaged renal cells such as various vitamins, trace elements, organic acid, amino acid. The DNA in the damaged cells will also be activated and this can speed up the repairing and recovery of kidney functions.

3. Immunotherapy

As to the causes of PKD, there is a new theory called two-hit which holds that only heredity of mutated polycystic gene (reproductive mutation) can not cause PKD. Only when the allele gene has mutation (somatic mutation) can PKD occur. That is why some patients can go through their entire life without PKD affecting their daily life even they have inherited the polycystic gene while some patients have symptoms and discomforts quite early.

The somatic mutation is induced by acquired factors after birth such as infections, poisoning, etc. Therefore PKD can be prevented if we can prevent the second hit, that is the somatic mutation. The key point is to build up physical strength, enhance immunity and at the same time stay away from risk factors.

Immunotherapy combines the advantages of Chinese therapy and western therapy and it can treat both the primary and secondary aspects of PKD at the same time. It can not only alleviate the symptoms but also regulate the disorders of the immune system and improve immunity so that patients can be strong enough to resist virous viruses and bacteria. This can help lower the incidence of second hit and recurrent rate.

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Can Polycystic Kidney Disease Affect Pregnancy

Can Polycystic Kidney Disease Affect Pregnancy

Can Polycystic Kidney Disease Affect Pregnancy

Can I have a baby? This is the common question posed by women with Polycystic Kidney Disease. As the genetic disease, Polycystic Kidney Disease always affects people’s life directly or indirectly. As to women, whether they can give a birth to is the problem they care the most. Well then, can woman with Polycystic Kidney Disease be pregnant at all?In general, if woman with Polycystic Kidney Disease have no high blood pressure, massive proteinuria and damages of renal function, then they are able to give a birth to and their disease will not be aggravated at the same time. Even though women with Polycystic Kidney Disease have the chance to be pregnant, during the period of pregnancy, they should attach importance to the following several points.First of all, women with Polycystic Kidney Disease should make their decision to have a baby after their illness condition is more stable. According to the clinical observation, if women with Polycystic Kidney Disease get their disease controlled before they give a birth to, then the heredity rate will be decreased greatly. Moreover, it also is benefits for their disease.Secondly, during the pregnancy period, women withPolycystic Kidney Disease should do examination regularly. The examination includes both tests on their disease and their baby. While do examination about the baby, if there are some abnormalities which means the baby was shown to have Polycystic Kidney Disease, then the parents should choose the proper way of termination of pregnancy.Thirdly, due to the hereditary character of Polycystic Kidney Disease, after the baby is born, the examination on baby should be continuous. Usually, the examination should be done once a half year.

Some women suffer from autosomal recessive PKD, which is a rare, inherited form of the disease. The cause is believed to be a genetic flaw. Parents without signs of the disease can have a baby who suffers from it, if both parents carry the abnormal gene. If only one parent carries the gene, the baby is safe but could act as a carrier and pass the gene to his or her own children .

Polycystic kidney disease causes the kidneys to lose their ability to rid the blood of wastes and keep your body’s chemicals and fluids balanced. Cysts grow and put pressure on other parts of the kidneys, resulting in high blood pressure and uremia, a condition of toxic levels of waste. As the disease progresses, the result may be end-stage renal failure. Pregnant women with polycystic kidney disease must be constantly monitored by their physician.

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How to Tell if I Have Cyst Infection in PKD

How to Tell if I Have Cyst Infection in PKD

How to Tell if I Have Cyst Infection in PKD

Cyst infection is a common symptom in PKD. However, the clinical determination of an infected cyst may be pretty difficult. Kidney infection is typically featured with high fever( usually >38°C ), abdominal pain and sometimes blood in urine. It is difficult to distinguish these symptoms from those caused by pyelonephritis, infected kidney stones, cyst hemorrhage or perihepatic abscess. So you are recommended to go to hospital and do further tests to see if you have cyst infection.

Conventionally, imaging tests may not be definitive in isolating the location of infection or even in differentiating cyst infection from cyst hemorrhage or pyelonephritis.You can rely more on blood cultures or cyst fluid aspiration to get a more accurate diagnosis. The accurate diagnosis of cyst infection is very important, because it can influence the initiation of antibiotics and determine the duration of antibiotic therapy.

If you are diagnosed with cyst infection, you should not delay its treatment. If left untreated, it may infect kidneys,abdominal cavity, or even blood, resulting in kidney infection, peritonitis and even sepsis. So it is a wise choice for you to seek for further inspection immediately.

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Polycystic Kidney Disease and Pregnancy

Polycystic Kidney Disease and Pregnancy

Polycystic Kidney Disease and Pregnancy

Any woman with Polycystic Kidney Disease should be constantly monitored by the doctor during their pregnancy. On one hand, most pregnant women with PKD have successful pregnancies; on the other hand, pregnancy may lead preeclampsia or miscarriage for PKD patients.

Risk of pregnancy for PKD patients

PKD patients are suggested to have a baby on the condition of stable kidney function. Due to the disease, pregnancy will overload the kidneys more, which may be a trigger of progressive kidney failure. This is dangerous for both mother-to-be and fetus.

Preeclampsia affects 5 to 8 percent of all pregnancies, which involves protein in urine and hypertension. You may also find other symptoms, such as sudden weight gain, headaches and changes in vision. Preeclampsica is a top factor to cause mother and infant illness and death.

Preparation for pregnancy

– Improve kidney function. Many treatments are available for Polycystic Kidney Disease. Besides drugs and surgery, natural treatments are also used to control PKD. Chinese Herbal Medicine, acupuncture, massage and Medicated Bath claim to control the cysts and improve kidney functon.

– Control blood pressure. High blood pressure is a common complication of both PKD and pregnancy. Hypertension increases the development of kidney failure, heart disease and stroke. It is dangerous for pregnancy.

– See your doctor at a regular basis. Talking with your doctor regularly is very important and beneficial to monitor the medical condition of mother-to-be and fetus.

Will I pass on PKD to my baby?

PKD is a typical inherited kidney disease. If one parent has the PKD history, the children will have as much as 50% chance to get the disease. If both parents have the disease, the children will have 75% of possibility to get PKD.

Autosomal recessive PKD can sometimes be detected before birth using a fetal ultrasound. It will show whether the fetus has enlarged kidneys, but it very rarely detects large cysts. Autosomal recessive PKD also scars the liver, so an image of that area can also help with diagnosis.

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Mental Health And Chronic Kidney Disease

You feel depressed or even hopeless when you are diagnosed with polycystic kidney disease, one of the refractory diseases around the world. With kidney disease, you take various medicines and try every therapy, hoping that you can get rid of it effectively. However, while you are seeking treatments, you are very likely to ignore your mental health which actually is as important as your physical state.

Polycystic kidney disease has a long course, during which you may encounter various annoying symptoms like itchy skin. You may feel bad and become angery easily, even if when you face your beloved one. You are guilty with your poor behaviour; however, you lose again in controlling your emotion next time. Kidney problem bothers you and in turn, poor emotion affect your recovery; therefore, learning to manage your emotion and trying to keep mental health are very important.

1. Ask your doctor for help

Tell your doctors about what you are physically feeling: pain, fatigue, dizziness or despair. Your doctors may calm you by telling encouraging words and then teach you some measures to deal with your physical discomforts.

2. Learn to be optimistic

Your mental health is actually up to your attitude toward chronic kidney disease. Chronic kidney disease is a refractory disease, but with timely and effective treatment, you are very likely to live a beautiful life without being affected by kidney problem. If you are free from kidney disease, I am sure you will have a better emotion. Therefore, do not lose your hope at any time and struggle against kidney disease bravely.

3. Communicate more with your friends and family members

Do not lock yourself in the room. Open your heart and go to communicate with your friends and family members. Communication is the best method to build confidence and it gets you the support you need.

Mental health is the precondition for one to recover quickly from disease. Around this world, many miracles appears because of confidence and attitude. Thereby, instead of giving up casually, heartening yourself up and we all believe you will be the real winner that defeating polycystic kidney disease.

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PKD and Kidney Failure

Metabolic acidosisKidney failure occurs when you are left with less than 10-15% of total kidney function. When the kidneys fail, dialysis treatment or a kidney transplant is needed. Not everyone with PKD will go on to develop kidney failure. On average, half of the people with the Type 1 variant of ADPKD will require treatment for kidney failure by age 60. However, people affected with the Type 2 variant have a lower risk for developing kidney failure. Children born with ARPKD usually develop kidney failure within a few years.

There are treatments available that help to delay progression of ADPKD.

Pharmacologic therapy is necessary to accomplish the following:

Control blood pressure

Control abnormalities related to renal failure

Treat urinary tract infections

Treat hematuria

Reduce abdominal pain produced by enlarged kidneys

Metabolic problems related to renal failure that need to be controlled include the following:

Hyperkalemia

Hyperphosphatemia

Hypocalcemia

Hyperparathyroidism

Metabolic acidosis

Recent research has led to the development of Chinese herbal medicine that may shrink cysts and prevent cysts from developing.

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Polycystic Kidney Disease with Blood in Urine

Blood in Urine

Blood in Urine

Polycystic kidney disease is a hereditary renal disease in which the kidneys are filled with numerous cysts of varying sizes. With the progressing of the disease condition, patients will often have blood in urine. Is blood in urine a serious condition and will it aggravate PKD?

Blood in urine is a common symptom of PKD and there are more than a half of PKD cases have this experience. When the bleeding is severe, it can cause renal colic when blood clots pass ureters. Blood in urine is often accompanied by leucocyte urine and protein in urine(usually less than 1.0g/d). If there is infection or inflammation in the kidneys, blood in urine will be worsened and there will also be obvious pyuria, back pain and fever.

What are the possible causes of blood in urine?

Blood in urine is mainly caused by the following reasons. One is renal hematuria. The compression of continuously enlarged cysts to surrounding renal tissues will damage the renal functional units and start the process of renal fibrosis. The glomerular basement membrane is damaged and its permeability is increased, as a result, the blood cells will pass through the glomerular filtration membrane and be discharged into urine and form hematuria. The other reason is rupture of blood vessels due to enlarged cysts. In addition, blood in urine can be caused by other reasons such as urinary tract infection, kidney stone or cancerization. If blood in urine lasts for more than one week or the patient is older than 50 years old, related tests should be done to rule out the possibility of cancerization.

What are the damage and danger of blood in urine?

Once there is blood in urine, patients are easy to have abdominal infection, high fever, systemic edema and sharp decline of renal function. Since blood urine in PKD is highly recurrent, patients are easy to have anemia—there will be sharp decrease of platelet and the blood coagulation mechanism will also be affected. In serious condition, it might cause renal failure.

What are the treatments for blood urine in PKD?

Since there are several causes of blood urine, the first step is to make clear the exact cause and remove it. Besides, patients should stop working and have good rest.

After blood in urine, most PKD patients develop infections which will in turn worsen hematuria, therefore proper prevention and treatments for infections are necessary.

Then more effective treatments should be offered to eliminating blood stasis and improving blood circulation. Whether it is the damaged glomerular filtration membrane or ruptured blood vessels, the root problem is the continuous enlargement of the cysts. Herbal medicines have good effect on alleviating hematuria in PKD. Active material from natural plants will provide necessary nutrition for repairing damaged renal tissues and improving renal function.

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